Understanding the Selectivity of CELMoDs in Targeting Cancer Cells

 


What is Multiple myeloma and How is it to be treated?

Multiple myeloma is a cancer of plasma cells, and it affects approximately 138,000 people worldwide. The multiple myeloma market is dominated by several drugs, with REVLIMID being the leading therapy. However, with the entry of CELMoDs, such as iberdomide, many believe that they could be a worthy successor to REVLIMID.

Generic competition to REVLIMID

REVLIMID, also known as lenalidomide, is one of the most widely prescribed drugs for multiple myeloma. However, the drug has faced significant competition in recent years, with the entry of generic versions in 2022. The introduction of generic REVLIMID has had a considerable impact on the multiple myeloma market, with many patients switching to cheaper alternatives.

The arrival of CELMODS

CELMoDs, or cereblon modulating drugs, are a new class of drugs that work in a similar way to REVLIMID. They are designed to modify the activity of cereblon, a protein that plays a crucial role in the function of the immune system. The first CELMoD to receive FDA approval was iberdomide in February 2022.

Mechanistic differences between CELMODs and IMiDs

IMiDs and CELMoDs share a common target, Cereblon, but CELMoDs are more selective and efficient in degrading proteins. Unlike IMiDs, which are known to have off-target effects, CELMoDs have been designed to bind selectively to Cereblon and target only the proteins involved in cancer cell growth. This selectivity is expected to translate into improved efficacy and safety.

Future of CELMODs

The future of CELMoDs looks promising, with several CELMoDs in the pipeline. Iberdomide, a novel CELMoD, has received FDA approval for clinical trials and has shown promising results in Phase 1 studies. This drug has shown a good safety profile and significant anti-tumor activity in patients with relapsed or refractory multiple myeloma. The drug's mechanism of action has also been found to be more potent than REVLIMID, making it a potential successor to REVLIMID.

Conclusion

The multiple myeloma market has seen significant advancements in the past few years, with new therapies such as CELMoDs emerging as a worthy successor to REVLIMID. These drugs have been designed to overcome the limitations of existing therapies and have shown promising results in preclinical and clinical studies. With the arrival of drugs like Iberdomide, the future of CELMoDs looks promising. However, the long-term efficacy and safety of these drugs need to be established through rigorous clinical trials. Nonetheless, CELMoDs offer hope for patients with multiple myeloma, providing new avenues for the treatment of this challenging disease.

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