Deucravacitinib: A Ray of Hope after a decade of wait! BMS plans to progress its potential game-changer oral TYK2 inhibitor into late-stage clinical development

Efficacy and safety of deucravacitinib, an oral, selective, allosteric TYK2 inhibitor, in patients with active Systemic Lupus Erythematosus (SLE): a Phase II, randomized, double-blind, placebo-controlled study (LB0004)

Bristol Myer Squibb’s deucravacitinib, which is an oral selective, allosteric tyrosine kinase 2 (TYK2) inhibitor has been evaluated for multiple immune-mediated diseases, including psoriasis arthritis, inflammatory bowel diseases, active discoid and subacute cutaneous lupus.


In the PAISLEY (NCT03252587) proof of concept study, the medication was compared to a placebo in individuals with moderate to severe SLE. Deucravacitinib (3 mg BID, 6 mg BID, and 12 mg QD) or placebo were given to patients on conventional background medicines. The proportion of patients who achieved SRI (4) at week 32 was the primary goal. Key secondary endpoints at week 48 included SRI (4), BICLA, LLDAS, CLASI-50, and change from baseline in the active (tender and swollen) joint count.


New systemic lupus treatments are desperately needed. New oral medicine has not been approved in decades, and up to half of the patients may not respond sufficiently to current treatment alternatives. These clinically meaningful results represent a huge potential step forward in the development of a new lupus therapy to help meet the immense need of patients living with this disease.

Conclusion 

Because systemic lupus erythematosus is such a varied disease, new therapeutic alternatives are needed because up to half of the patients may not respond well to present treatments. Deucravacitinib's positive safety, tolerability, and efficacy results in several measures of disease activity, including overall and organ-specific activity, when compared to the placebo group for the treatment of SLE, represent a huge potential step forward in the development of a new lupus therapy to help meet the immense need for patients living with this disease.


For more detailed information visit: https://www.delveinsight.com/eular-conference/eular-2022

 

Some of the Latest Abstracts launched in EULAR 2022:

 

Related Reports:

 

Diagnostic Imaging Equipment Market

Diagnostic Imaging Equipment Market By Product (X-Ray Imaging Systems, Computed Tomography (CT) Scanners, Ultrasound Systems, Magnetic Resonance Imaging (MRI) Systems, Nuclear Imaging Systems, Mammography Systems, And Others), By Application (Cardiology, Oncology, Gastroenterology, Gynecology, And Other Applications), By End-User (Hospitals, Diagnostic Imaging Centres, And Others), by geography is expected to grow at a steady CAGR forecast till 2026 owing to rising technological advancement and increasing prevalence of chronic diseases.

 

Invasive Candidiasis Market

"DelveInsight’s ‘Invasive Candidiasis Market Insight, Competitive Landscape and Market Forecast, 2027’ report delivers an in-depth understanding of Invasive Candidiasis and the historical and forecasted Invasive Candidiasis market trends, globally, which comprises North America, Europe, APAC, and RoW.

 

Sialidosis Market 

DelveInsight's "Sialidosis Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of the Sialidosis, historical and forecasted epidemiology as well as the Sialidosis market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.

 

Filgrastim Biosimilar Insight

DelveInsight’s, “Filgrastim Biosimilar Insight, 2022,” report provides comprehensive insights about 20+ companies and 20+ marketed and pipeline drugs in the Filgrastim Biosimilars landscape. It covers the marketed and pipeline drug profiles, including clinical and non-clinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. 

 

Pain Management Devices Market

Pain Management Devices Market By Type Of Devices (Neuromodulation & Neurostimulation Devices, Analgesic Infusion Pumps [Intrathecal Infusion Pumps and External Infusion Pumps], Ablation Devices [Radiofrequency Ablation Devices And Cryoablation Devices], And Others), By Application (Neuropathic Pain, Cancer Pain, Facial & Migraine Pain, Musculoskeletal Pain, and Others), By Geography is expected to grow at a steady CAGR Forecast till 2027.

 

To know more about our Competitive Services, Click here: Pharma Competitive Intelligence


Also, take a glance at the Blogs by DelveInsight:

Comments

Post a Comment

Popular posts from this blog

Understanding the Selectivity of CELMoDs in Targeting Cancer Cells

Image
  What is Multiple myeloma and How is it to be treated? Multiple myeloma is a cancer of plasma cells, and it affects approximately 138,000 people worldwide. The multiple myeloma market is dominated by several drugs, with REVLIMID being the leading therapy. However, with the entry of CELMoDs , such as iberdomide, many believe that they could be a worthy successor to REVLIMID. Generic competition to REVLIMID REVLIMID, also known as lenalidomide, is one of the most widely prescribed drugs for multiple myeloma . However, the drug has faced significant competition in recent years, with the entry of generic versions in 2022. The introduction of generic REVLIMID has had a considerable impact on the multiple myeloma market , with many patients switching to cheaper alternatives. The arrival of CELMODS CELMoDs, or cereblon modulating drugs, are a new class of drugs that work in a similar way to REVLIMID. They are designed to modify the activity of cereblon, a protein that plays a crucial r...
Read more

Hopeful Horizons: Advancing Multiple System Atrophy Treatment Strategies

Image
Neurodegenerative diseases like Multiple System Atrophy (MSA) pose significant challenges to patients and the medical community. However, ongoing research and promising therapeutic approaches offer hope for better management and potential treatments. In this blog, we'll explore the latest developments in MSA treatment. Neurodegenerative Connections: Similarities Between Multiple System Atrophy and Parkinson’s Disease Multiple System Atrophy shares clinical and pathological features with Parkinson's Disease (PD) . Both conditions are characterized by the accumulation of abnormal alpha-synuclein protein in the brain. Understanding these shared characteristics has led to potential crossover treatments, as advancements in PD research may benefit MSA patients. Breaking Ground: Promising Multiple System Atrophy Treatment Approaches 1. Samsara BioCapital's Investment: Samsara BioCapital's funding in MSA research has been instrumental in driving innovative treatment strategi...
Read more

The Emergence of Advanced Ocular Implant Technologies

Image
The ocular implants market is a rapidly growing industry that involves the use of medical devices to improve vision and treat eye conditions. Ocular implants are artificial devices that are placed within the eye to replace or supplement natural eye structures. In this blog, we will discuss what ocular implants are, their major benefits and drawbacks, regional market assessment, key companies in the ocular implants market, and future market assessment. What are Ocular Implants? Ocular implants are medical devices that are designed to improve vision and treat eye conditions such as cataracts , glaucoma , diabetic retinopathy , and macular degeneration. These devices are made of various materials, including silicone, acrylic, and polymethyl methacrylate (PMMA), and are surgically implanted into the eye. Ocular Implants – Major Benefits and Drawbacks The major benefits of ocular implants are improved vision and reduced dependence on glasses or contact lenses. They can also treat various ...
Read more